beta-2 transferrin|Cerebrospinal Fluid (CSF) Leak : Tagatay Detection of a beta-2 transferrin band by immunofixation is indicative of the presence of cerebrospinal fluid in the specimen. Beta-2 transferrin is also found in aqueous humor. Rare allelic variants of transferrin may cause false positive results in the detection of CSF leakage.
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beta-2 transferrin,
Beta-2 Transferrin, Body Fluid - Presence of Beta-2 Transferrin (B2T) in nose and ear secretions is indicative of cerebrospinal fluid (CSF) leakage. B2T is used as a marker of CSF leakage for the diagnosis of rhinorrhea or otorrhea as a result of head trauma, tumor, congenital malformation, surgery etc. Prompt diagnosis and localization helps .Beta-2 transferrin is a CSF-specific variant of transferrin and is used as an endogenous marker of CSF leakage. Beta-2 transferrin is formed by loss of sialic acid due to the presence of neuraminidase in the central nervous system.Cerebrospinal Fluid (CSF) Leak β-2 transferrin is a protein found in CSF, but not in serum, nasal secretions, or adjacent tissue. Testing fluid from the ear or nose for β-2 transferrin is the recommended method to assess patients for a cranial CSF leak because this approach .
Beta-2 transferrin is a carbohydrate -free (desialated) isoform of transferrin, which is almost exclusively found in the cerebrospinal fluid. It is not found in blood, mucus or tears, thus making it a specific marker of cerebrospinal fluid, applied as an assay in cases where cerebrospinal fluid leakage is suspected. [1]
Since that time, beta-2-transferrin has been used extensively by otolaryngologists in the diagnosis of CSF rhinorrhoea and skull-base cerebrospinal fluid fistulas. With sensitivity of 94% - 100%, and specificity of 98% - 100% 5, this assay has become the .
Detection of a beta-2 transferrin band by immunofixation is indicative of the presence of cerebrospinal fluid in the specimen. Beta-2 transferrin is also found in aqueous humor. Rare allelic variants of transferrin may cause false positive results in the detection of CSF leakage.Symptoms of a CSF leak include: If your doctor suspects a CSF leak, he or she may recommend the following tests. Analysis of the nasal fluid: This test is used to detect beta-2 transferrin, a protein found almost exclusively in CSF.
Beta-2-transferrin is a protein produced by neuraminidase activity in the brain which is uniquely found in the cerebrospinal fluid (CSF) and perilymph. Its absence in other body secretions makes its detection invaluable in diagnosing a CSF leak.beta-2 transferrinBeta-2-transferrin is a protein produced by neuraminidase activity in the brain which is uniquely found in the cerebrospinal fluid (CSF) and perilymph. Its absence in other body secretions makes its detection invaluable in diagnosing a CSF leak.
beta-2 transferrin|Cerebrospinal Fluid (CSF) Leak
PH0 · Use of Beta
PH1 · Cerebrospinal Fluid (CSF) Leak
PH2 · Beta
PH3 · BETA2